Specifically, this mutant shows decreased catalase activity indicating a misregulation of ROS scavenging mechanisms.

A Δ tor1Δ slm35 strain shows a severe decrease in lifespan and is unable to contend with oxidative and heat shock stresses. In this work we report that in Saccharomyces cerevisiae, the uncharacterized mitochondrial protein Slm35 is functionally linked with the TOR signaling pathway. A deficiency in any of these genes promotes lifespan extension and cell protection during oxidative and heat shock stress. It has been previously shown that Tor1, Sch9 and Ras2 are activated in response to nutrient availability and regulate cell growth and division. Aging depends on a balance between mitochondrial biogenesis, function and degradation. One of the physiological processes linked to mitochondria is aging, a gradual process of damage accumulation that eventually promotes cell death. In most eukaryotic cells mitochondria are essential organelles involved in a great variety of cellular functions.

2016 tor links