Some of it may not apply to your particular situation, but the Important Points section does, and it's easier to cut and paste than retype same info

Never to late to post in a relevant thread, and you're using Memory Blocks Log, so you need to know if the it's hitting maximum, which will cause a CTD. I should also say that I'm using the 'SKSE.ini for lazy user setting' not sure if that helps. Hey guys, I don't know if its too late to write on this thread or not but I kinda have the same issue, my 1st block is set to 512 mb and the 2nd block is 256 mb but I get a CTD around 15 mins of playing and it always occur around 15 min to 20 min, My system is pretty good for skyrim, ( Core i7 7700K and 1060 3gb EVGA, 8 gb ram) when I read the memory block log, i see that 2nd block fills first then the 1st one then a CTD, It doesn't matter at what location I play, I just get a CTD of 15-20 mins of playing whatsoever, My skyrim is pretty loaded though I have around 216 mods, also I did a save clean and the FPS is 60 consistently.

How to load enb with skse loader